Construction and Functional Characterization of Random Peptide Libraries for Phage Surface Display Targeting Metal-Binding Applications

Helmholtz-Zentrum Dresden-Rossendorf HZDR (Forschungsstelle Leipzig)

01328 Dresden

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Overview

This Master thesis focuses on the development and characterization of random peptide libraries for application in phage surface display.
The aim is to explore new strategies for generating and analyzing functional peptide sequences.
The project includes the design and molecular construction of peptide libraries as well as their experimental evaluation in terms of diversity and basic functional properties.
Initial studies on the interaction of selected peptides with target structures will also be performed.
The work combines molecular biology and combinatorial biotechnology and provides insight into the development of innovative biomolecular systems.
Department: Pep2Rec
Contact: Dr. Schönberger, Nora, Giefer, Patrick, Techert, Gerda, Ates, Oguzcan

Design and molecular construction of peptide libraries
Experimental evaluation of peptide libraries for diversity and basic functional properties
Initial studies on interactions of selected peptides with target structures
Work within an interdisciplinary junior research group

Enrolled in a Master’s program at a university, preferably with a focus on molecular biology or a related field
Practical experience in molecular biology techniques (e.g., cloning, transformation, PCR, sequencing techniques)
Familiarity with genetic engineering safety regulations
Basic knowledge of bioinformatic analysis of sequencing data
Initial experience in in silico peptide modeling is desirable