Construction and Functional Characterization of Random Peptide Libraries for Phage Surface Display Targeting Metal-Binding Applications

Helmholtz-Zentrum Dresden-Rossendorf HZDR (Forschungsstelle Leipzig)

01328 Dresden

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Master theses

This Master thesis focuses on the development and characterization of random peptide libraries for application in phage surface display.
The aim is to explore new strategies for generating and analyzing functional peptide sequences.
The project includes the design and molecular construction of peptide libraries as well as their experimental evaluation in terms of diversity and basic functional properties.
Initial studies on the interaction of selected peptides with target structures will also be performed.
The work combines molecular biology and combinatorial biotechnology and provides insight into the development of innovative biomolecular systems.

Design and molecular construction of peptide libraries for phage surface display.
Experimentally evaluate libraries in terms of diversity and basic functional properties.
Initial studies on the interaction of selected peptides with target structures.
Work within an international team as part of the Pep2Rec department.
Collaborate within an interdisciplinary junior research group.

Enrolled in a Master’s program at a university, preferably with a focus on molecular biology or a related field.
Practical experience in molecular biology techniques (e.g., cloning, transformation, PCR, sequencing techniques).
Familiarity with genetic engineering safety regulations.
Basic knowledge of bioinformatic analysis of sequencing data.
Initial experience in in silico peptide modeling is desirable.